Recently, African diaspora leaders, African Union Ambassador and country ambassadors, ministers of health from Africa, philanthropists, religious leaders, global health scholars, students, advocates, and industry leaders met at the GHC summits at Harvard Medical School, Johns Hopkins, and University of Pennsylvania to discuss opportunities and strategies to collaborate in addressing the growing global burden of cancer tearing through Africa and other global health disparities. With over 700 thousand deaths and a million new cases a year from cancer alone, the ever increasing burden of non-communicable diseases (NCDs) in Africa has been described as a growing health iceberg, hidden under epidemics of infectious diseases that needs to be urgently addressed.  A salient feature of the GHC summits has been the unprecedented level of participation by hundreds of Africans in Diaspora (AiD) leaders looking to turn a negative history of slavery and brain drain into positive global health gain. The African Union defines the African diaspora as all peoples of African descent living outside of Africa, a constituency that maintains deep, affective, and material ties to the continent.  GHC has been at the forefront of engaging the diaspora, as catalysts of win-win USA-Africa collaborations for global health and development.